Androgen Receptor Polyglutamine Repeat Length Affects Receptor Activity and C2c12 Cell Myogenic Potential
نویسندگان
چکیده
Title of Document: ANDROGEN RECEPTOR POLYGLUTAMINE REPEAT LENGTH AFFECTS RECEPTOR ACTIVITY AND C2C12 CELL MYOGENIC POTENTIAL
منابع مشابه
CALL FOR PAPERS Functional Analysis of Sequence Variation Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development
Sheppard RL, Spangenburg EE, Chin ER, Roth SM. Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development. Physiol Genomics 43: 1135–1143, 2011. First published August 9, 2011; doi:10.1152/physiolgenomics.00049.2011.—Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR...
متن کاملAndrogen receptor polyglutamine repeat length affects receptor activity and C2C12 cell development.
Testosterone (T) has an anabolic effect on skeletal muscle and is believed to exert its local effects via the androgen receptor (AR). The AR harbors a polymorphic stretch of glutamine repeats demonstrated to inversely affect receptor transcriptional activity in prostate and kidney cells. The effects of AR glutamine repeat length on skeletal muscle are unknown. In this study we examined the effe...
متن کاملAssessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran
Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...
متن کاملRecruitment of the androgen receptor via serum response factor facilitates expression of a myogenic gene.
Androgen receptor (AR) induced precocious myogenesis in culture and myogenic specified gene activity. Increased levels of AR expression in replicating C2C12 myoblasts stimulated fusion into post-differentiated multinucleated myotubes and the appearance of skeletal alpha-actin transcripts, even in the absence of ligand. Furthermore, AR activated the skeletal alpha-actin promoter, which lacks GRE...
متن کاملSelective androgen receptor modulator, YK11, regulates myogenic differentiation of C2C12 myoblasts by follistatin expression.
The myogenic differentiation of C2C12 myoblast cells is induced by the novel androgen receptor (AR) partial agonist, (17α,20E)-17,20-[(1-methoxyethylidene)bis-(oxy)]-3-oxo-19-norpregna-4,20-diene-21-carboxylic acid methyl ester (YK11), as well as by dihydrotestosterone (DHT). YK11 is a selective androgen receptor modulator (SARM), which activates AR without the N/C interaction. In this study, w...
متن کامل